
Late final month, the EPA authorized a brand new “endlessly chemical” pesticide to be used on meals crops. Isocycloseram is a member of the notorious perfluoroalkyl and polyfluoroalkyl substances (PFAS), a gaggle of extremely persistent compounds which were linked to hormone disruption and an elevated danger of most cancers.
PFAS are often known as ‘endlessly chemical substances’ as a result of they’re bioaccumulative, binding to proteins within the blood, liver, and kidneys — to not point out in water sources and within the soil. Isocycloseram particularly has been related to male reproductive points like diminished testicle measurement and decrease sperm depend1. Regardless of these regarding hyperlinks, the compound has now been authorized to be used by the EPA on meals crops like oranges, tomatoes, almonds, peas, and oats. The chemical will also be used to deal with golf programs and lawns.
Approval on a Technicality


On November 26, the EPA revealed a information launch framed as a “truth verify” to justify their approval of the pesticide in query2. The discharge centered on the truth that as a single fluorinated compound, Isocycloseram doesn’t technically fall underneath the 2023 EPA PFAS definition established throughout the Biden administration. Whereas this can be the case, it’s a loophole at greatest — the Organisation for Financial Co-operation and Growth defines PFAS as “fluorinated substances that include no less than one absolutely fluorinated methyl or methylene carbon atom3.”
Technicalities apart, Isocycloseram may be categorized as reasonably pervasive, with a half-life of over three years4. Furthermore, it’s identified to rework into 40 smaller PFAS chemical substances like trifluoroacetic acid, which is exponentially extra persistent than Isocycloseram. And like many PFAS-containing pesticides, Isocycloseram can also be extremely poisonous to bees and different pollinators.
A Regarding PFAS Pesticide Sample


Isocycloseram is the second PFAS pesticide to be authorized since Trump took workplace, following cyclobutrifluram, which earned approval simply two weeks earlier than. And in additional regarding EPA PFAS information, the administration has plans to approve three extra poisonous pesticides containing endlessly chemical substances within the coming yr.
“To approve extra PFAS pesticides amid the rising consciousness of the intense, long-term risks from these endlessly chemical substances is absurdly shortsighted,” mentioned Nathan Donley, environmental well being science director on the Heart for Organic Range. “The simple actuality is that the Trump administration is knowingly placing the nation’s youngsters at higher danger of growing severe reproductive and liver harms for generations to come back.”
Sources:
- https://downloads.laws.gov/EPA-HQ-OPP-2021-0641-0015/content material.pdf
- https://www.epa.gov/newsreleases/fact-check-epa-debunks-false-claims-agency-recently-approved-forever-chemical
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10827356/
- https://cen.acs.org/setting/pesticides/4-new-pesticides-ignite-debate/103/net/2025/06

